A New Direction for Oral Bone Grafting in China
In the field of dental implant restoration, the choice of bone filling material directly affects surgical outcomes and patient prognosis. For years, bovine-derived bone filling materials have dominated the domestic market, with porcine-derived domestic products remaining entirely absent.
The launch of PoroGraft® changed this landscape. As China's first xenograft bone filling material derived from porcine bone, PoroGraft® is setting a new benchmark for oral bone grafting through three core technological advantages.
Core Advantage One: Rare Porcine Femoral Metaphyseal Cancellous Bone
PoroGraft® strictly selects porcine femoral metaphyseal cancellous bone as its raw material source. This anatomical site is one of the most structurally refined regions in the porcine skeleton — only 20-40g of wet femoral metaphyseal cancellous bone can be extracted from a single pig, making the raw material extremely rare and valuable.
The natural three-dimensional interconnected trabecular structure at this site is highly similar to human cancellous bone, with porosity approaching that of human cancellous bone, providing an ideal three-dimensional scaffold for bone regeneration. Compared to bone tissue from other sites, metaphyseal cancellous bone has a more organized microstructure and higher biological activity.
Core Advantage Two: Gradient Temperature-Rising Calcination for High-Purity Quality
Medgen employs a proprietary gradient temperature-rising calcination process, precisely controlling the temperature increase to completely preserve the natural reticular pore structure while effectively removing organic components and impurities, achieving the following quality benchmarks:
- Purity ≥95%: Thorough removal of organic components that could trigger immune responses
- Crystallinity ≥95%: Far exceeding the approximately 65% crystallinity of natural bone, with superior structural stability
- Strict virus inactivation: Ensuring biological safety
- Preserved natural microporous structure: Guaranteeing excellent osteoconductive performance
The core principle of the gradient temperature process is to avoid the destruction of natural bone microstructure from rapid high-temperature exposure. By gradually increasing temperature, organic components are fully decomposed and removed, achieving an optimal balance between purity and structural integrity.
Core Advantage Three: Calcium-Phosphorus Ratio and Zinc-Magnesium Content Similar to Human Bone
The chemical composition of PoroGraft® closely resembles that of human skeletal tissue:
- Calcium-phosphorus ratio similar to human bone: Natural chemical affinity enables better integration into the bone metabolic cycle
- Rich zinc and magnesium ion content: Zinc promotes osteoblast proliferation and differentiation; magnesium participates in the bone mineralization process
- High biocompatibility: Pigs share high genetic similarity with humans, resulting in low rejection risk
These natural chemical advantages enable PoroGraft® to efficiently induce bone regeneration, achieving stable bone formation with high bone density within 3-6 months.
Clinical Applications and Outlook
PoroGraft® has received NMPA Class III medical device certification and is indicated for extraction site preservation, alveolar ridge augmentation, maxillary sinus lift, peri-implant bone defect repair, and guided bone regeneration (GBR).
As China's first domestically developed porcine oral bone graft, PoroGraft® is driving Chinese oral bone repair materials into a new stage of development through independent innovation and technological excellence.